Re: Any one know SMTP and PHP integration?
Look at the settings for your mailbox (this can be found on the hosting control panel page). From there you can set up "auto responder". An autoreponder will send a pre-determined email message to any email address from which it receives an email.
Alternately, google "opensource php pop3 class" and find out a tested, reliable class that can read email from a POP3 account. You can then set up a cron job that runs, say, every hour and poll the pop3 mailbox. you can write simple php function to send a (customized??) response For every new message that is present in the mailbox.
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