Don't run msconfig unless you know what you're doing though... it can ruin a lot of things if you arent careful...
I would recommend Windows Defender and Adaware SE Personal...
run disk cleanup in teh start menu, all programs, accessories, system tools...
and run disk defragmenter...
Get rid of norton if you have it
Those are all great things to do...
Registry Cleaners arent going to boost the speed of your computer if you run all those thigns that i told you before...
Also, if your computer came with any trial software... i would recommend removing it.
Hope Everything works out well!
Mitch